Recent developments centered on orally active iron chelators
نویسندگان
چکیده
منابع مشابه
Antimalarial properties of orally active iron chelators.
The appearance of widespread multiple drug resistance in human malaria has intensified the search for new antimalarial compounds. Metal chelators, especially those with high affinity for iron, represent one presently unexploited class of antimalarials. Unfortunately the use of previously identified chelators as antimalarials has been precluded by their toxicity and, in the case of desferrioxami...
متن کاملMultidentate terephthalamidate and hydroxypyridonate ligands: towards new orally active chelators.
The limitations of current therapies for the treatment of iron overload or radioisotope contamination have stimulated efforts to develop new orally bioavailable iron and actinide chelators. Siderophore-inspired tetradentate, hexadentate and octadentate terephthalamidate and hydroxypyridonate ligands were evaluated in vivo as selective and efficacious iron or actinide chelating agents, with seve...
متن کاملIron chelators as anti-neoplastic agents: current developments and promise of the PIH class of chelators.
The chelator currently used to treat iron (Fe) overload disease, desferrioxamine (DFO), has shown anti-proliferative activity against leukemia and neuroblastoma cells in vitro, in vivo and in clinical trials. Collectively, these studies suggest that Fe-deprivation may be a useful anti-cancer strategy. However, the efficacy of DFO is severely limited due to its poor ability to permeate cell memb...
متن کاملPhytoestrogens: recent developments
Phytoestrogens are polyphenolic non-steroidal plant compounds with estrogen like activity exerted through estrogen receptors. These receptors are distributed in several tissues such as male and female reproductive systems, bones, cardiovascular and central nervous systems. These natural phenolic compounds include isoflavonoids, flavonoids, lignans and stilbenes. Isoflavonoids are the most studi...
متن کاملPhytoestrogens: recent developments
Phytoestrogens are polyphenolic non-steroidal plant compounds with estrogen like activity exerted through estrogen receptors. These receptors are distributed in several tissues such as male and female reproductive systems, bones, cardiovascular and central nervous systems. These natural phenolic compounds include isoflavonoids, flavonoids, lignans and stilbenes. Isoflavonoids are the most studi...
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ژورنال
عنوان ژورنال: Thalassemia Reports
سال: 2014
ISSN: 2039-4365,2039-4357
DOI: 10.4081/thal.2014.s1.2261